Table 2.
Types of antimicrobial therapy and impacts on outcome
| Treatment and outcome (no. of patients) | No. (%) of patients with outcome: |
Pa | ORa | 95% CIa | |
|---|---|---|---|---|---|
| Present | Absent | ||||
| Empirical therapy | |||||
| Cefepime alone (43) | |||||
| Mortality | 17 (40) | 26 (60.5) | 0.7 | 1.19 | 0.57–2.49 |
| Readmission | 13 (30) | 30 (70) | 0.8 | 1.14 | 0.52–2.50 |
| Cefepime alone or in combination (69) | |||||
| Mortality | 26 (38) | 43 (62.3) | 0.86 | 1.09 | 0.55–2.15 |
| Readmission | 17 (25) | 52 (75.4) | 0.3 | 0.70 | 0.34–1.47 |
| Carbapenem alone (14) | |||||
| Mortality | 5 (36) | 9 (64.3) | 1.0 | 0.96 | 0.30–3.03 |
| Readmission | 2 (14.3) | 12 (86) | 0.3 | 0.39 | 0.08–1.83 |
| Carbapenem alone or in combination (40) | |||||
| Mortality | 15 (38) | 25 (63) | 1.0 | 1.05 | 0.49–2.24 |
| Readmission | 7 (17.5) | 33 (80.5) | 0.09 | 0.44 | 0.17–1.13 |
| Consolidative Therapy | |||||
| Cefepime alone (9) | |||||
| Mortality | 3 (33.3) | 6 (67) | 1.00 | 0.86 | 0.20– 3.59 |
| Readmission | 5 (56) | 4 (44) | 0.12 | 3.47 | 0.88–13.64 |
| Cefepime alone or in combination (31) | |||||
| Mortality | 9 (29) | 22 (71) | 0.40 | 0.65 | 0.27–1.54 |
| Readmission | 9 (29) | 22 (71) | 1.00 | 1.04 | 0.43–2.5 |
| Carbapenem alone (33) | |||||
| Mortality | 12 (36.4) | 21 (64) | 1.00 | 0.98 | 0.44–2.21 |
| Readmission | 9 (27) | 24 (73) | 1.00 | 0.93 | 0.39–2.23 |
| Carbapenem alone or in combination (78) | |||||
| Mortality | 25 (32) | 53 (68) | 0.23 | 0.65 | 0.33–1.29 |
| Readmission | 21 (27) | 57 (73) | 0.71 | 0.86 | 0.41–1.78 |
a
These analyses were conducted by comparing patients who had the antibiotic exposure variable to patients who did not have the antibiotic exposure variable.