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Ki values for wild-type and mutant DHFR enzymes
| Compound | Ki (± SD) for Sa | Ki (± SD) for Sa (F98Y) | Fold loss (F98Y/Sa) | Ki (± SD) for Sa (F98I) | Fold loss (F98I/Sa) | Ki (± SD) for Sa (H30N) | Fold loss (H30N/Sa) |
|---|---|---|---|---|---|---|---|
| TMP | 0.0033 (± 0.00048) | 0.10 (± 0.0073) | 30 | 0.13 (± 0.051) | 39 | 0.0066 (± 0.0012) | 2.0 |
| 1 | 0.0028 (± 0.00041) | 0.012 (± 0.00088) | 4.3 | 0.055 (± 0.022) | 20 | 0.0059 (± 0.0011) | 2.1 |
| 2 | 0.011 (± 0.0016) | 0.023 (± 0.0017) | 2.1 | 0.17 (± 0.067) | 16 | 0.55 (± 0.10) | 50 |
