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. 2012 Jun;86(12):6656–6667. doi: 10.1128/JVI.00174-12

Fig 8.

Fig 8

LMP2A, Fra-1, and MMP9 are associated in NPC tumor biopsy specimens. (A) Shown are the typical patterns for positive (+) and negative (−) immunohistochemical staining of LMP2A, LMP1, Fra-1, and MMP9 in NPC tissue sections. (B) Mediation analysis of LMP2A, Fra-1, and MMP9 was performed. The effective coefficients, 95% CIs, and P values are provided. The overall effect of LMP2A on MMP9 (c), the effect of LMP2A on Fra-1 (a), and the effect of Fra-1 on MMP9 (b) were all positive and statistically significant. The Fra-1-mediated effect between LMP2A and MMP9, ab, was also significant and contributed more than half (57%) of the overall effect of LMP2A on MMP9. On the other hand, the Fra-1-independent effect of LMP2A on MMP9 (c′) was relatively weak. (C) Mediation analysis of LMP1, Fra-1, and MMP9 was performed as described for panel B. The statistical results were similar to those for LMP2A, except that the Fra-1-independent effect of LMP1 on MMP9 (c′) existed significantly.