Fig 5.

Significantly increased numbers of leukocytes infiltrate the livers of LCMV-infected STAT1 KO mice. Shown is FACS analysis of leukocytes isolated from the livers of WT and STAT1 KO mice at day 6 postinfection. Compared with uninfected WT mice, livers from infected WT mice showed slight increases in the numbers of CD4⁺ (A) and CD8⁺ (C) T cells, neutrophils (E), and macrophages (G). In contrast, large numbers of CD4⁺ (A) and CD8⁺ (C) T cells, neutrophils (E), and macrophages (G) infiltrated the liver in STAT1 KO mice following infection. Notably, neutrophils were the most frequent cell type, followed by macrophages and CD8⁺ T cells. (B, D, F, and H) Percentages of populations in respect to all live cells. Data are shown as means and SEM. *, **, and ***, P < 0.05, P < 0.01, and P < 0.001 as determined by Mann-Whitney U test.