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Crystal structure of BNP. (A) Two molecules in the asymmetric unit of the BNP crystal structure. (B) BNP forms a crystallographic tetramer, with the tail loop inserting in the order of A-B′-A″-B‴-A. (C) BNP (surface representation in blue) inserts its tail loop into the neighboring molecule (pink). (D) Structural organization of BNP (chain A). α-Helices and β-strands are numbered. Antiparallel β-strands are denoted with “−”.
