Fig 4.

Static light scattering and coimmunoprecipitation of the homo-oligomerization mutants. (A) Static light scattering of wild-type (WT) and tail loop-deleted BNP. Curves are the refractive interference signal. Values are native molecular masses of BNP in the population of the peaks. (B) Static light scattering of the polymerase activity-defective BNP variants, compared to the wild type. (C) Coimmunoprecipitation of BNP oligomerization mutants. BNP without RNA-binding activity (WT/G1) could self-interact and served as the positive control. All BNP oligomerization mutants with defective polymerase activity could not homo-oligomerize.