Fig 5.

EM analyses showing the different viral assembly and maturation defects induced by BM and BD inhibitors. Images show transmission electron micrographs of thin-sectioned concentrated virions released from cells treated with DMSO (control) (A), BD 1 (B), or BM 3 (C). Enlargements of 3 individual virions are shown below each representative field. Inhibitor treatments were performed as for the experiments shown in Fig. 4. Similar results were also obtained with BD 4 (rare, highly aberrant virions) and BM 1 (acentric, nonconical cores). The experiments were performed twice, and similar results were obtained in both cases. Bars, 100 nm.