Fig 6.
Identities and structural locations of viral resistance mutations selected by treatment with BD (A) and BM (B) inhibitors. Two compounds from each chemical series were used for the selection of resistant virus: BD 1 and BD 2 from the BD series and BM 2 and BM 3 from the BM series (see Table 1 for compound structures and activities). Resistance substitutions (highlighted in red; side chains shown in stick form) selected by these compounds are mapped onto the CANTD Cα trace (gray), with bound BD and BM inhibitors shown in orange (BD 3) and blue (BM 4).