Fig 7.

Inhibitor resistance substitutions reduce viral fitness. Shown are levels of luciferase produced by Jurkat LTR-luciferase reporter cells 14 days after infection with wild-type HIV-1 or with viruses carrying the designated mutations within the CA protein that confer resistance to BD inhibitors or BM inhibitors. The major G208A polymorphism was also tested. Luciferase activities are expressed as relative replicative capacities, with that for the wild-type virus set at 100%. Replicative capacities were measured at days 7, 12, and 14. The results for each mutant were similar on days 12 and 14. Replicative capacity was not assessed at additional times owing to the potential for variability over longer periods. Each value represents the average for 6 replicates from a typical experiment.