Table 3.
Inhibition of postentry (early) versus postintegration (late) stages of virus replication
| Compound | Value for single-cycle assaysa |
EC50 (μM) for multiple-cycle assays | ||
|---|---|---|---|---|
| Early EC50 (μM) | Late EC50 (μM) | Cytotoxicityb (CC50 [μM]) | ||
| BD 1 | 2.8 | 0.2 | >7.0 | 0.06 |
| BM 2 | 3.2 | 0.2 | 6.2 | 0.26 |
| Lopinavir | >0.5 | 0.01 | >0.5 | 0.009 |
| Nevirapine | 0.08 | >2.2 | >2.2 | 0.02 |
a
Boldface values denote the expected result for late- and early-stage activities of Lopinavir and Nevirapine, respectively.
b
Cytotoxicity was determined on virus producer cells (late phase).