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Energetics of inhibitor binding to CANTDa
| Compound | KD (μM) | ΔG (kcal/mol) | ΔH (kcal/mol) | −TΔS (kcal/mol) |
|---|---|---|---|---|
| BM 2 | 0.210 | −9.12 | −18.3 | 9.21 |
| BM 3 | 0.087 | −9.64 | −18.7 | 9.06 |
| BD 2 | 0.690 | −8.40 | −7.50 | −0.90 |
Inhibitor binding was quantified by isothermal titration calorimetry (see Materials and Methods).
