Table 5.
Susceptibilities of viruses with resistance mutations to inhibitors of capsid assembly
| Compound | Fold change from the EC50 of the wild-type virus with the following mutationa: |
|||||||
|---|---|---|---|---|---|---|---|---|
| V27I (BD) | V36T (BD) | K30R (BM) | T58Ia (BM and BD) | G208R (BM and BD) | G208A | K30R G208R (BM) | V36T G208R (BD) | |
| BD 1 | 5 | 25 | 1 | 6 | 3 | 1 | 4 | >36 |
| BM 2 | 1 | 8 | 4 | 16 | 7 | 1 | 16 | 55 |
| BM 3 | 1 | 7 | 5 | 22 | 5 | 1 | 5 | 35 |
a
The class(es) of compound with which each mutation was selected is given in parentheses. T58I was a major substitution selected with BM compounds but a minor substitution selected with BD compounds. G208A is a natural polymorphism.