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Reduction in affinity for BM compounds by resistance substitutions
| Compound | Fold change from the KD of the compound for wild-type CANTDa with the following mutation: |
||||
|---|---|---|---|---|---|
| S33G | V27A | V36T | T58I | K30R | |
| BM 2 | 13 | 6 | 16 | 0.9 | NDb |
| BM 5 | 14 | 10 | 18 | 1.1 | 0.9 |
The KDs of BM 2 and BM 5 for wild-type CANTD were 210 and 170 nM, respectively.
ND, not determined.
