Table 2.
Baseline characteristics of patients according to serum 25-OHD levels
| Without 25-OHD deficiency (n = 65) | With 25-OHD deficiency (n = 41) | P- values | |
|---|---|---|---|
| 25-OHD (ng/ml) |
16.7 ± 0.6 |
7.3 ± 0.3 |
< 0.001 |
| Demographic characteristics |
|
|
|
| Recipient age (years) |
40.5 ± 1.3 |
39.9 ± 1.8 |
0.793 |
| Recipient gender (% women) |
12 (18.5) |
19 (46.3) |
0.002 |
| Active vitamin D supplementation before KT |
13 (20.0) |
4 (9.8) |
0.186 |
| Etiology of renal failure (%) |
|
|
|
| Diabetes mellitus |
5 (7.7) |
5 (12.2) |
0.440 |
| Glomerulonephritis |
17 (26.2) |
15 (36.6) |
0.255 |
| Hypertension and others |
43 (66.2) |
21 (51.2) |
0.126 |
| Duration on dialysis (months) |
19.1 ± 3.7 |
13.3 ± 3.9 |
0.309 |
| History of cardiovascular disease |
5 (7.7) |
3 (7.3) |
0.943 |
| Smoking |
15 (23.1) |
7 (17.1) |
0.458 |
| Body mass index (kg/m2) |
23.2 ± 0.4 |
22.2 ± 0.4 |
0.102 |
| Predominant RRT modality before KT (%) |
|
|
|
| Hemodialysis |
42 (64.6) |
7 (17.1) |
< 0.001 |
| Peritoneal dialysis |
6 (9.2) |
16 (39.0) |
< 0.001 |
| Pre-emptive transplantation |
17 (26.2) |
18 (43.9) |
0.058 |
| Transplant type |
|
|
|
| Living-related donor |
44 (67.7) |
32 (78.0) |
0.249 |
| Living-unrelated donor |
20 (30.8) |
9 (22.0) |
0.321 |
| Deceased donor |
1 (1.5) |
0 (0.0) |
1.000 |
| Donor characteristic |
|
|
|
| Donor age |
35.2 ± 1.4 |
35.0 ± 1.5 |
0.922 |
| Donor gender (% women) |
36 (56.3) |
23 (56.1) |
0.988 |
| ABO mismatch (%) |
12 (18.8) |
3 (7.3) |
0.153 |
| Number of HLA mismatches |
2.9 ± 0.2 |
2.8 ± 0.2 |
0.753 |
| Mismatch at A locus (%) |
49 (76.6) |
34 (82.9) |
0.434 |
| Mismatch at B locus (%) |
55 (85.9) |
35 (85.4) |
0.935 |
| Mismatch at DR locus (%) |
52 (81.3) |
35 (95.4) |
0.585 |
| Biopsy-proven acute rejection episode |
2 (3.1) |
9 (22.0) |
0.003 |
| Laboratory test results |
|
|
|
| Albumin (g/dl) |
4.0 ± 0.1 |
3.6 ± 0.1 |
< 0.001 |
| Calcium (mg/dl) |
9.4 ± 0.1 |
8.7 ± 0.2 |
0.004 |
| Albumin-corrected calcium (mg/dl) |
9.4 ± 0.1 |
9.1 ± 0.2 |
0.121 |
| Phosphorus (mg/dl) |
6.0 ± 0.3 |
5.5 ± 0.2 |
0.169 |
| Alkaline phosphatase (IU/l) |
68.9 ± 3.3 |
68.0 ± 4.4 |
0.864 |
| Parathyroid hormone (intact; pg/ml) |
205.4 ± 26.9 |
203.2 ± 29.2 |
0.957 |
| Osteocalcin (ng/ml) |
47.7 ± 5.4 |
41.2 ± 5.5 |
0.429 |
| Hemoglobin (g/l) | 9.8 ± 0.2 | 9.0 ± 0.3 | 0.028 |
Results are expressed as mean ± SEM or number (%).
KT, kidney transplantation; RRT, renal replacement therapy.