Table 1.
Percentage of patients whose Hb dropped by ≥2 g/dl (cases), by study site and risk factors
| ΔHb ≥ 2 g/dl (%) | p-value* | ||
|---|---|---|---|
|
Site |
|
|
|
| Mozambique Manhiça |
23.4 |
(49/209) |
0.015 |
| Uganda Mbarara |
23.8 |
(41/172) |
|
| Uganda Tororo |
8.6 |
(8/93) |
|
| Uganda Jinja |
19.6 |
(19/97) |
|
|
Sex |
|
|
|
| Boys |
21.1 |
(64/303) |
0.691 |
| Girls |
19.8 |
(53/268) |
|
|
Age, months |
|
|
|
| 12–27 |
35.3 |
(38/248) |
0.026 |
| 28–43 |
25.1 |
(51/203) |
|
| 44–60 |
23.3 |
(28/120) |
|
|
Mild anaemia (Hb < 11 g/dl) |
|
|
|
| Yes |
13.9 |
(63/452) |
<0.001 |
| No |
45.4 |
(54/119) |
|
|
Parasite density |
|
|
|
| Low (<29623 μl-1) |
15.5 |
(39/251) |
0.034 |
| High (>29623 μl-1) |
24.4 |
(78/320) |
|
|
Treatment |
|
|
|
| CDA |
22.0 |
(42/191) |
0.312 |
| AL |
13.1 |
(8/61) |
|
| DHAPQ |
18.9 |
(36/190) |
|
| AQ + AS | 24.0 | (31/129) | |
CDA = chlorproguanil-daspone + artesunate. AL = artemether-lumefantrine. DHAPQ = dihydroartemisinin-piperaquine. AQ + AS = amodiaquine-artesunate.
*Chi-square test.