Figure 4. Results of functional annotation clustering of up- and down-regulated A. gambiae genes at 10 and 17dpi when compare with uninfected mosquitoes.

Clusters with an enrichment score >1 (value in brackets) are colored, clusters with scores <1 are greyed out. (A) At 10 dpi, the down-regulated genes were grouped into 9 discrete clusters, with genes up-regulated in response to P. berghei infection grouped into 3 discrete clusters; (B) At 17dpi, the significantly over-represented functions of down-regulated genes are less diverse than 10dpi with carbohydrate catabolism represented at both time points. At this time point up-regulated genes make up 2 clusters.