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. 2012 Jul 10;7(7):e40671. doi: 10.1371/journal.pone.0040671

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Steinestel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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and B, Regular mucosa (A) and wild-type hyperplastic polyps (B) show only moderate, cytoplasmatic and basally located Abi1 immunoreactivity. Note intense staining of lymphocytes in subjacent stroma. C, Overexpression of Abi1 in a representative hyperplastic polyp harboring KRAS G12D mutation. D-F, Intense immunoreactivity in (wild-type) sessile serrated adenoma (D), traditional serrated adenoma (E) and tubular adenoma (F). Note that positivity for Abi1 is exclusively cytoplasmic. G and H, strong immunoreactivity for Abi1 in invasive colorectal carcinoma and in a liver metastasis of colorectal carcinoma. I, strong cytoplasmic immunoreactivity for Abi1 in inflamed colonic mucosa. Stain: anti-Abi1, haematoxylin; Bar indicates 200 µm.