Table 2.
Comparison of Genotypic Drug Resistance Between Study Arms
| Mothers | Triple ARV | AZT/sd-NVP |
|---|---|---|
| Total enrolled in Burkina and South-Africa | 271 | 264 |
| Sample available <6 weeks after cessation of ARV | 152 | 75 controls |
| VL >1000 copies/mL | 90 | 48 |
| Could be sequenced | 72 | 41 |
| Total with resistance | 1/72 | 7/41a |
| NNRTI resistance | K101E | K103N: n = 3; V106L: n = 3; Y188C: n = 1 |
Abbreviations: ARV, antiretroviral; AZT/sdNVP, zidovudine until delivery with single-dose nevirapine without postpartum prophylaxis; NNRTI, nonnucleoside reverse transcriptase inhibitor; Triple ARV, zidovudine, lamivudine, and lopinavir/ritonavir during pregnancy and breastfeeding; VL, viral load.
a Zero of 12 women who received an AZT/3TC tail for 1 week after delivery; 7 out of 29 women who received no tail.