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. 2012 Jul 10;7(7):e40235. doi: 10.1371/journal.pone.0040235

Figure 7. Schematic illustrating BK channel structure and sites of variable splicing in the BK alpha-subunit of slow-twitch soleus (Sol) and fast-twitch flexor digitorum brevis (FDB) skeletal muscles, and the related channel models.

Figure 7

Five variants were found in the slow-twitch and fast-twitch skeletal muscles: e17 in C1, +29aa or e22 in C2, and Slo27 or Slo0 in C4 sites. These variants participate in the composition of the tetramers. The variants e22 and Slo27 characterizing the BK channels of the FDB and Sol muscle phenotypes, respectively, are shown. BK channels containing e22 variant are sensitive to bendroflumethiazide (BFT) while those containing Slo27 are sensitive to resveratrol (RESV).