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. Author manuscript; available in PMC: 2012 Jul 10.
Published in final edited form as: Eur J Immunol. 2010 Aug;40(8):2103–2106. doi: 10.1002/eji.201040482

Figure 2. DC Compartmentalization in Lymphoid Tissues.

Figure 2

Schematic representation of DC subset localization within skin-draining LN (left panel) and spleen (right panel). Even though all migratory DCs appear to enter the draining LN through the interfollicular region, dermal DC are thought to be positioned near the B cell follicles and the Langerhans cells to be positioned deeper in the T cell zone with other resident DCs. Resident CD8α+ DCs have also recently been shown to have distinct compertmenalization in skin-draining LN. Differences in resident DC subset localization have also been noted in the spleen, with specific regionalization of CD8α+ and 33D1+ DC between the white and red pulp.