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. Author manuscript; available in PMC: 2013 Jan 5.
Published in final edited form as: Nature. 2012 Jul 5;487(7405):104–108. doi: 10.1038/nature11225

Figure 1. Saturated MF-induced colitis is associated with bloom of Bilophila wadsworthia (Bw) in IL10−/− mice.

Figure 1

a,g Samples from SPF C57BL/6 (n=6/group), and b–g, SPF IL10−/− mice fed MF, PUFA or LF for 24 weeks (n=20/group). a, Phyla representation shown for LF, PUFA, and MF with means ± S.E.M. *P<.05 compared to LF, #P<.05 compared to PUFA and LF. b, Gross incidence of colitis. c, Representative colon lengths (top) and H&E staining of distal colon (bottom). Scale bars, 400µm. d, Blinded histological colitis scores25. e, Distal colonic mucosal cytokines determined by ELISA. f, PCoA plot of the UNIFRAC metric matrix. g, Q-PCR of cecal content dsrA (normalized to LF diet).