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. Author manuscript; available in PMC: 2013 Jan 5.
Published in final edited form as: Nature. 2012 Jul 5;487(7405):86–89. doi: 10.1038/nature11189

Figure 1. Origin and evolution of a proposal for a direct, enantioselective, and regioselective allylation of β-diketones.

Figure 1

a Retrosynthesis of the AB spiroketal of spongistatin 1 to β-hydroxyketone 1. b A direct asymmetric allylation of acetylacetone would have to contend with the enol form of the diketone. c The generalization of a direct method would require control of regioselectivity.