Table 3. Top 10 pathways associated with genes showing altered expression in AD subjects identified using GeneGO Metacore software.
| Pathway Rank |
Pathway Name | p-Value | Number of Differentially Expressed Genes |
Number of Genes in Pathway |
|---|---|---|---|---|
| 1 | Immune response_IL-15 signaling via JAK-STAT cascade | 1.639E-04 | 4 | 23 |
| 2 | Apoptosis and survival_Endoplasmic reticulum stress response pathway | 4.732E-04 | 5 | 53 |
| 3 | Development_Prolactin receptor signaling | 7.195E-04 | 5 | 58 |
| 4 | Development_EPO-induced Jak-STAT pathway | 8.648E-04 | 4 | 35 |
| 5 | Immune response_IL-15 signaling | 1.129E-03 | 5 | 64 |
| 6 | G-protein signaling_Regulation of p38 and JNK signaling mediated by G- proteins |
1.308E-03 | 4 | 39 |
| 7 | Apoptosis and survival_TNFR1 signaling pathway | 1.890E-03 | 4 | 43 |
| 8 | Development_Thrombopoetin signaling via JAK-STAT pathway | 2.394E-03 | 3 | 22 |
| 9 | Immune response_IL-2 activation and signaling pathway | 3.066E-03 | 4 | 49 |
| 10 | Development_GM-CSF signaling | 3.301E-03 | 4 | 50 |