TABLE 1.
Data Inputs for Variables in Our Model
| Variable | Type of distribution |
Mea | Standard deviation |
Rangea |
|---|---|---|---|---|
| Cost, US$ | ||||
| Surveillanceb | γ | 9.52 | 1.62 | … |
| Decolonizationb | γ | 103.95 | 17.10 | … |
| Vancomycin, per day12 | γ | 9.01 | 5.00 | … |
| Procedures | ||||
| Graft replacement13 | γ | 1224.46 | 197.00 | … |
| Amputation13 | γ | 864.88 | 137.00 | … |
| Surgical revision of stump infection13 | γ | 625.03 | 93.00 | … |
| IV replacement14 | γ | 141.99 | 23.00 | … |
| Chest x-ray13 | γ | 42.36 | 4.5 | … |
| Hospitalization cost | ||||
| Wound infection13 | γ | 4,683 | 1,767 | … |
| Graft infection13 | γ | 12,958 | 365 | … |
| Amputation13 | γ | 11,922 | 4,061 | … |
| Infected stump13 | γ | 7,789 | 647 | … |
| Line infection14 | γ | 24,581 | 17,394 | … |
| Urinary tract infection13 | γ | 5,050 | 129 | … |
| Pneumonia13 | γ | 13,047 | 478 | … |
| Utilities, QALYs | ||||
| Wound infection15 | … | 0.642 | … | … |
| Graft infectionb | … | 0.53 | … | … |
| Amputation16 | … | 0.44 | … | … |
| Stump infection17 | … | 0.3 | … | … |
| Line infection18 | … | 0.642 | … | … |
| Urinary tract infection16 | … | 0.73 | … | … |
| Pneumonia16 | … | 0.58 | … | … |
| Probabilities | ||||
| Surveillance: true positive19 | β | 0.7985 | 0.0196 | … |
| Surveillance: false positive19 | β | 0.0415 | 0.0044 | … |
| Given MRSA colonization: | ||||
| MRSA infection11 | β | 0.2990 | 0.1233 | … |
| Given MRSA infection: | ||||
| Wound infection2,4–6,9,10,20 | β | 0.6071 | 0.1156 | … |
| Graft infection2–4 | β | 0.2133 | 0.4011 | … |
| Line infection5 | β | 0.0239 | 0.0015 | … |
| Urinary tract infection4,5 | β | 0.0833 | 0.0168 | … |
| Pneumonia2,5,6,9,10 | β | 0.1667 | 0.0738 | … |
| Given wound infection: | ||||
| Amputation5,7,9 | β | 0.4048 | 0.2495 | … |
| Given graft infection: | ||||
| Amputation1–3 | β | 0.6087 | 0.3059 | … |
| Given amputation: | ||||
| Stump infection8,20 | β | 0.5667 | 0.0471 | … |
| Mortality rate | ||||
| Wound infection4 | β | 0.5295 | 0.0050 | … |
| Graft infection1,2 | β | 0.3611 | 0.1964 | … |
| Line infectionb | β | 0.1005 | 0.0937 | … |
| Pneumonia2,9 | β | 0.1875 | 0.0884 | … |
| Urinary tract infectionb | β | 0.0498 | 0.0218 | … |
| Duration, days | ||||
| Antibiotic administration | ||||
| Wound infectionb | Uniform | … | … | 10–14 |
| Graft infectionb | Uniform | … | … | 28–42 |
| Amputationb | Uniform | … | … | 10–14 |
| Stump infectionb | Uniform | … | … | 10–14 |
| Line infectionb | Uniform | … | … | 14–28 |
| Urinary tract infectionb | Uniform | … | … | 10–14 |
| Pneumoniab | Uniform | … | … | 10–14 |
| Length of stayc | ||||
| Wound infection13 | … | 3.0 | … | … |
| Graft infection13 | … | 7.0 | … | … |
| Amputation13 | … | 8.0 | … | … |
| Stump infection13 | … | 5.0 | … | … |
| Line infection21 | … | 6.0 | … | … |
| Urinary tract infection13 | … | 4.0 | … | … |
| Pneumonia13 | … | 9.0 | … | … |
NOTE. QALY, quality-adjusted life year.
a
Lower limit–upper limit for uniform distribution.
b
Source: expert consultation.
c
Length of stay is expressed as median, not mean.