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Combinatorial specificities of MutS- and MutL-related heterocomplexes. (a) Base/base mispairs; (b) insertion/deletion mispairs; (c) 5′ tailed DNA structures generated by single-strand DNA annealing (SSA) recombination; (d) Holliday junctions. Note that the DNA binding specificity for MSH4–MSH5 and its interaction with MLH1–MLH3 have not been shown. MLH1–MLH2 is not indicated, because it is not clear with which MutS-related complex it interacts.
