Table 2.

Patient Disposition

Starting Combination Dose of Sunitinib, mg/day + IFN-α,* MU 3 Times Weekly (n)	Final† Combination Dose of Sunitinib, mg/day + IFN-α, MU 3 Times Weekly (n)
37.5 + 3 (13)	37.5 + 6 (1) 37.5 + 3 (7) 37.5 + 0 (1) 25 + 3 (3) 25 + 0 (1)
50 + 3 (12)‡	37.5 + 6 (4) 37.5 + 3 (3) 37.5 + 0 (1) 25 + 3 (2) 25 + 0 (2)

^*Patients were subject to intrapatient dose escalation of IFN-α weekly, as tolerated, to a maximum dose of 9 MU, which, per a protocol amendment, was discontinued during cycle 1, making 6 MU the highest IFN-α dose thereafter. In addition, 6 patients, per the final protocol amendment, were newly enrolled on sunitinib 37.5 mg plus IFN-α 3 MU and not subject to dose escalation of IFN-α.

^†The combination dose received by patients as of the data cutoff.

^‡One patient on sunitinib 50 mg/day mistakenly co-administered a starting dose of IFN-α 10 MU, necessitating a dose titration to 3 MU.

Abbreviation: IFN = interferon