Fig. (1).

Structures of NBCe1 variants and pRTA-related mutations. Different patterns in the squares indicate unique amino acids sequences. While NBCe1-A has a unique N-terminal, NBCe1-C has a unique C-terminal. Numbers in circles indicate pRTA-related NBCe1 mutations corresponding to Q29X (1), R298S (2), S427L (3), T485S (4), G486R (5), R510H (6), W516X (7), L522P (8), N721TxfsX29 (9), A799V (10), R881C (11), and S982NfsX4 (12). Q29X is an NBCe1-A specific mutation, leaving NBCe1-B and NBCe1-C intact. S982NfsX4 creates a flame-shift mutation in NBCe1-A and NBCe1-B, but may suppress the translation of NBCe1-C. The remaining mutations lie in the common region of NBCe1 variants.