Fig. (1).

An illustrative Circulatory Syndrome; A cluster of cardiac, renal, arterial and circulatory markers of disease that are interconnected through the endothelium; the common media (underlying factors) include oxidative stress, inflammation, hypercoagulability state and endotheliopathy which contribute in the main mechanisms of the phenomena; the third dimetion (precipitating factors) include age, obesity, physical inactivity and smoking which accelerate the phenomena