Table 2.

Statistical comparison of prothrombin time INR endpoints following the administration of a single oral dose of 30 mg warfarin alone (day 1, treatment A) and co-administered with multiple once daily doses of 100 mg anacetrapib (day 1, treatment B) in healthy adult subjects (n = 12 for treatment A, n = 11 for INR_max in treatment B and n = 10 for INR AUC_{(0–168 h)} in treatment B)

	Warfarin + anacetrapib			Warfarin alone			Warfarin + anacetrapib : warfarin alone
Parameter	n	GM	95% CI	n	GM	95% CI	GMR	90% CI	rMSE†
INR AUC(0–168 h)‡	10	206.77	(190.44, 224.50)	12	223.25	(206.05, 241.89)	0.93	(0.89, 0.96)	0.0464
INRmax‡	11	1.63	(1.38, 1.93)	12	1.92	(1.63, 2.26)	0.85	(0.76, 0.96)	0.1497

^†rMSE: Root mean square error on log scale. When multiplied by 100, provides estimate of the pooled within-subject coefficient of variation.

^‡Back-transformed least squares mean and confidence interval from mixed effects model performed on natural log transformed values. INR AUC_{(0–168 h)} value was not calculable for subject AN 0002, Treatment B, as subject withdrew consent after 72 h. GM geometric mean, GMR geometric mean ratio.