Table 1.

‘Serious’ : ‘non-serious’ adverse drug reaction (ADR) ratios and number of reported ADRs over time for the 16 drugs for which linear trend tests were possible

	‘Serious’ : ‘Non-serious’ adverse drug reaction ratios (total number of reports) per year
Drugs	2000	2001	2002	2003	2004	2005	2006	2007	2008	2009	2010	P
Celecoxib	0.22 (n = 28)	0.70 (n = 503)	0.99 (n = 189)	1.61 (n = 128)	1.35 (n = 134)	2.42 (n = 82)	2.40 (n = 34)	1.16 (n = 41)	1.31 (n = 37)	1.92 (n = 38)	2.40 (n = 31)	0.0165
Esomeprazole	–	–	0.59 (n = 27)	0.52 (n = 41)	0.96 (n = 100)	1.42 (n = 138)	1.17 (n = 180)	1.03 (n = 176)	1.21 (n = 208)	1.42 (n = 278)	1.90 (n = 278)	0.0033
Etanercept	2.33 (n = 20)	1.14 (n = 30)	2.12 (n = 25)	1.37 (n = 57)	1.94 (n = 100)	1.77 (n = 119)	3.12 (n = 103)	1.36 (n = 118)	1.82 (n = 141)	2.05 (n = 107)	2.87 (n = 93)	0.3312
Galantamine	–	4.00 (n = 5)	1.91 (n = 32)	1.12 (n = 34)	1.08 (n = 25)	0.50 (n = 21)	2.43 (n = 24)	1.77 (n = 36)	2.44 (n = 31)	0.88 (n = 32)	0.55 (n = 31)	0.7351
Interferon α	0.77 (n = 53)	0.78 (n = 32)	2.00 (n = 18)	0.85 (n = 37)	0.86 (n = 26)	1.25 (n = 27)	1.40 (n = 12)	0.67 (n = 25)	0.89 (n = 17)	2.33 (n = 10)	3.00 (n = 12)	0.0760
Interferon β	1.00 (n = 14)	0.92 (n = 23)	0.60 (n = 8)	0.29 (n = 9)	1.30 (n = 7)	2.00 (n = 9)	0.30 (n = 13)	3.00 (n = 8)	1.25 (n = 9)	3.00 (n = 4)	2.00 (n = 6)	0.1271
Levetiracetam	–	2 (n = 6)	0.67 (n = 10)	1.00 (n = 12)	1.33 (n = 21)	0.94 (n = 35)	0.69 (n = 27)	1.03 (n = 73)	0.95 (n = 127)	1.07 (n = 116)	1.26 (n = 86)	0.4857
Oxcarbazepine	–	0.71 (n = 48)	0.82 (n = 62)	0.71 (n = 77)	0.90 (n = 80)	1.00 (n = 58)	1.22 (n = 60)	1.37 (n = 45)	0.83 (n = 42)	1.05 (n = 43)	1.13 (n = 32)	0.0515
Oxycodone	–	–	–	– (n = 1)	– (n = 2)	4.00 (n = 5)	4.00 (n = 15)	4.67 (n = 17)	3.75 (n = 19)	2.25 (n = 26)	1.29 (n = 39)	0.0394
Peginterferon-α2a	–	0.75 (n = 7)	0.77 (n = 85)	0.79 (n = 77)	0.94 (n = 68)	1.05 (n = 39)	1.42 (n = 29)	1.54 (n = 28)	2.14 (n = 22)	2.50 (n = 28)	4.00 (n = 10)	0.0006
Pioglitazone	–	–	– (n = 3)	0.22 (n = 11)	0.30 (n = 13)	0.50 (n = 15)	0.73 (n = 19)	1.07 (n = 29)	1.00 (n = 24)	3.00 (n = 24)	2.50 (n = 7)	0.0036
Risedronate	–	0.25 (n = 15)	0.56 (n = 36)	0.64 (n = 36)	0.38 (n = 29)	1.50 (n = 35)	0.80 (n = 45)	1.00 (n = 32)	0.68 (n = 32)	1.29 (n = 32)	3.00 (n = 24)	0.0197
Rosiglitazone	–	–	– (n = 1)	0.62 (n = 13)	0.75 (n = 14)	1.50 (n = 20)	1.00 (n = 12)	1.10 (n = 19)	1.80 (n = 14)	5.00 (n = 6)	2.00 (n = 3)	0.0503
Tibolone	–	0 (n = 9)	0.10 (n = 11)	0.12 (n = 9)	0.33 (n = 12)	– (n = 3)	– (n = 2)	0.25 (n = 5)	– (n = 2)	– (n = 2)	– (n = 0)	0.1367
Trastuzumab	– (n = 2)	4 (n = 5)	3 (n = 12)	0.62 (n = 13)	1.25 (n = 18)	2.14 (n = 22)	0.86 (n = 52)	0.88 (n = 68)	2.69 (n = 59)	2.28 (n = 59)	2.12 (n = 53)	0.6811
Verteporfin	–	0.87 (n = 15)	0.17 (n = 40)	0.24 (n = 31)	– (n = 3)	0.5 (n = 6)	1.33 (n = 7)	0.5 (n = 6)	– (n = 1)	– (n = 2)	– (n = 0)	0.5882