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Relationship between cathepsin-mediated ProSense 680 activation and tumor volume. Linear regression analysis of ovarian tumor volume determined by MRI or caliper measurements and cathepsin-mediated activation of the NIRF imaging probe ProSense 680 in tumors. Data from in vivo imaging by MRI and FMT were analyzed to compare (A) tumor volume determined by MRI versus caliper measurements, (B) probe retention versus MRI tumor volume, and (C) probe retention versus caliper tumor volume.
