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. 2012 Jul 11;13:45. doi: 10.1186/1471-2202-13-45

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Copyright ©2012 Oikawa et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the CreativeCommons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricteduse, distribution, and reproduction in any medium, provided the originalwork is properly cited.

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Search strategy assignments during Morris water maze testing. Search strategies were assigned for each mouse during the acquisition phase. Search strategies were categorized into three main groups: Spatial, Non-spatial Systematic, and Peripheral Looping. The data (right panel) show a disturbance in the formation of spatial memory in the p50^−/− mice as represented by fluctuations in their usage of spatial search strategies. p50^+/+ mice, on the other hand (left panel) show an expected gradual and steady increase in the proficient use of this hippocampal-dependent spatial strategy over time, which is consistent with several other studies. Chi-square tests showed several significant associations (P < 0.05) between strain and the adopted search strategies (days 2, 3, 4, and 7).