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. 2012 Jul 11;9:73. doi: 10.1186/1742-2094-9-73

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Copyright ©2012 Shi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The NALP3 inflammasome participates in tumor necrosis factor and chemokine (C-C motif) ligand (CCL)3 mRNA upregualtion in PrP106-126-stimulated microglia. Real-time quantitative PCR analysis of the mRNA level of TNF-α and CCL3 in BV2 cells treated for 12 hours with PrP106-126 after small interfering (si)RNA-mediated silencing of (a) NALP3 and (b) ASC siRNA silencing. Data represent the mean ± SD of triplicate samples from one of three independent experiments. *P < 0.05, significantly different from PrP106-126 treated cells.