Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jun 7;40(Web Server issue):W110–W116. doi: 10.1093/nar/gks365

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — The specificity profile (PWM) for the I-AniI LHE. Specificity profiles, reported as PWMs that have been experimentally determined for a number of LHEs can be entered individually and are available on the site as part of the browser functionality. These matrices are displayed in graphical format as a sequence logo plot (left) and in tabular format. The ability of the enzyme to cleave DNA targets that contain a given nucleotide at a specific position within the target site is indicated by letter height, and positions with greater overall information content are more specifically recognized. The profile displayed in this figure was determined in a series of biochemical experiments where the cleavability of target site variants was individually measured (34).