Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jun 9;40(Web Server issue):W263–W270. doi: 10.1093/nar/gks541

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — The MMI networks of H. sapiens, M. musculus and D. rerio. (A) Five major cellular processes in MMI networks in H. sapiens. (B) The node degree distribution of MMI network in H. sapiens follows a power law. The MMI network is a scale-free network. (C) The neighboring module network between the JAK2–PAFR–TYK2 module (CORUM ID: 5178) and its 25 neighboring modules. These modules can be roughly divided into three groups, including cell surface receptor linked signaling pathway (orange), cellular protein metabolic pathway (purple) and interleukine receptor signaling pathway (blue). Neighboring modules are highly consensus on two GO terms that are signal transducer activity and cytosol. (D) The inter-module PPIs (red lines) and the topology between modules JAK2–PAFR–TYK2 and the hexameric human IL-6/IL-6α receptor/gp130 (PDB code: 1p9m).