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Gene rearrangements, common gene rearrangements in cancer cells. (b) Shows the deletion of some genes at the DNA level which leads to depletion of corresponding mRNA. (c) Represents the fusion of two genes that leads to fused mRNA and fused proteins. (d) Represents special rearrangement type that fuses a strong promoter of gene A to the 5' of gene B. This leads to underexpression of gene A and overexpression of gene B.
