Table 2.
Selected genes highly mutated in colon cancer tumor genomes
| Gene | Protein Accession | Mutations | Protein Length |
|---|---|---|---|
| APC | NP_001120982 | 76 | 2843 |
| BRAF | NP_004324 | 14 | 766 |
| FBXW7 | NP_361014 | 21 | 745 |
| KRAS | NP_203524 | 30 | 189 |
| LOC440563 | NP_001130033 | 33 | 293 |
| NRAS | NP_002515 | 7 | 189 |
| OR8U1 | NP_001005204 | 48 | 309 |
| TAS2R19 | NP_795369 | 22 | 299 |
| TAS2R30 | NP_001091112 | 28 | 319 |
| TAS2R31 | NP_795366 | 31 | 309 |
| TAS2R43 | NP_795365 | 36 | 309 |
| TP53 | NP_000537 | 31 | 393 |
Selected list of significantly mutated genes as identified by using local false discovery rate (LFDR) (threshold < 0.1) of the length normalized mutation frequencies for all genes. Mutation counts are the total counts of somatic mutations identified in 100 colon cancer patients falling inside the protein coding region of the gene. Protein length is the number of amino acids in the representative protein isoform for the corresponding gene.