Table 2.

In vivo activity following a single oral dose of 400 mg/kg of selected 3-alkoxy-1,2-dioxolanes in mice harbouring juvenile or adult S. mansoni

Group	No. of mice investigated	No. of mice that died	No. of mice cured	TWR (%)	P value	FWBR (%)	P value
Control	8	0	0	−	−	−	−
Juvenile infection
1	4	0	0	0	0.73	0	0.86
2	4	0	0	4.1	0.67	5.9	0.38
3	4	0	0	0	0.87	0	0.44
Adult infection
1	4	0	0	42.5	0.27	47.1	0.23
2	4	0	0	37.0	0.35	41.2	0.35
3	4	0	0	15.1	0.86	17.7	0.73

TWR, total worm burden reduction; FWBR, female worm burden reduction.