Table 3.
In vivo activity following a single oral dose of 400 mg/kg of selected 3-alkoxy-1,2-dioxolanes in mice harbouring adult S. mansoni
| Group | No. of mice investigated | No. of mice that died | No. of mice cured | TWR (%) | P value | FWBR (%) | P value |
|---|---|---|---|---|---|---|---|
| Controla | 7 | 0 | 0 | − | − | − | − |
| Controlb | 9 | 0 | 0 | − | − | − | − |
| 15a | 4 | 1 | 0 | 32.0 | 0.1 | 37.8 | 0.1 |
| 16a | 4 | 1 | 0 | 12.0 | 0.7 | 5.4 | 0.7 |
| 17a | 4 | 1 | 0 | 21.3 | 0.4 | 35.1 | 0.3 |
| 18b | 4 | 0 | 0 | 16.4 | 0.9 | 11.9 | 0.7 |
TWR, total worm burden reduction; FWBR, female worm burden reduction.
aVersus control.
bVersus control.