Figure 7. Inhibition of MMP-1 activity suppresses the cytokine storm in WT mice but not PAR1-deficient mice.

Cytokine levels in WT mice or Par1^−/− mice subjected to CLP and injected immediately with either vehicle or MMP-Inh-1 (MMP Inh). After 24 h, plasma was collected and analysed using BD Mouse Inflammation cytometric multiplexing beads and cytokine content was measured using flow cytometry (n = 4–6), except KC was quantified using ELISA (n = 4). p < 0.05 versus vehicle.