Figure 1. Comparison of probucol-treated and untreated B6.Pdss2^kd/kd mouse kidney pathology.

Near-normal glomerular histology is evident upon haematoxylin and eosin staining of renal sections from male probucol-treated missense mutant mice shown at 100X magnification.

1. Wild-type B6 control.
2. Probucol-treated B6.Pdss2^kd/kd missense mutant mouse; 128-day old; 0.77 mg urine albumin.
3. Untreated B6.Pdss2^kd/kd missense mutant mouse; 132-day old; 7.3 mg urine albumin. Note tubular dilatation (arrow A), glomerular crescents (arrow B) and severe interstitial inflammation (arrow C) evident in kidney from untreated missense mutant mouse.