Table 4.

Mean (standard deviation) age of multiple sclerosis (MS) symptom onset among NARCOMS participants according to the number of comorbidities reported at MS onset in a physical comorbidity category (n = 8893)

Comorbidity Category	Number of Comorbidities Reported
	0	1	2	3
Vasculara	30.7 (8.8) (n= 8403)	36.9 (9.0) (n= 489)	42.0 (9.1) (n=76)	45.5 (7.5) (n= 13)
Autoimmunea	31.0 (9.0) (n= 8572)	35.1 (9.3) (n=388)	35.9 (7.7) (n= 21)	39.0 (15.6) (n= 2)
Visuala	31.1 (9.0) (n= 8920)	36.6 (10.6) (n=62)	25.0 (−)(n= 1)	-
Gastrointestinala	31.0 (9.0) (n=8420)	33.3 (8.8) (n= 490)	34.7 (7.5) (n=69)	32.0 (6.2) (n=4)
Musculoskeletala	31.1 (9.0) (n=8742)	35.3 (9.6) (n= 224)	41.7 (9.3) (n=16)	53.0 (−)(n= 1)

Vascular = diabetes, hypertension, heart disease, peripheral vascular disease, hypercholesterolemia; Autoimmune = autoimmune thyroid disease; uveitis; systemic lupus erythematosus; rheumatoid arthritis; inflammatory bowel disease; Sjogren’s disease; Gastrointestinal = peptic ulcer disease; irritable bowel syndrome; inflammatory bowel disease, liver disease; Musculoskeletal = fibromyalgia, arthritis, rheumatoid arthritis, systemic lupus erythematosus, hip replacement, knee replacement; Visual = uveitis, cataracts, glaucoma Means compared between groups using unbalanced ANOVA, adjusted for sex, race, education, and adjusted for multiple comparisons; a- P for linear trend age of onset ≤ 0.0001