APPENDIX A.

Treatment options (refer to Appendix B for recommended dosages and schedules)

First-line treatment alternatives	Second-line treatment alternatives
folfiri (combination 5-fu/fa/irinotecan)	folfox (combination 5-fu/fa/oxaliplatin), after first-line folfiri
folfox (combination 5-fu/fa/oxaliplatin)	folfiri (combination 5-fu/fa/irinotecan), after first-line folfox
de Gramont schedule (infusional 5-fu/fa)	folfox (combination 5-fu/fa/oxaliplatin), plus bevacizumab
Raltitrexed	Irinotecan alone
Capecitabine