Table 2. Continuous variable analysis of ESR1_TA, ESR2_CA, and AR_CAG alleles and breast cancer risk in African American and Nigerian women.
Repeat length, mean ± SD | Mann-Whitney P 2 | Logistic regression P 2, OR (95% CI) | |||||||||
Microsatellite | Allele1 | AA Case | AA Control | NG Case | NG Control | AA | NG | AA + NG3 | AA | NG | AA + NG |
ESR1_TA | S | 15.32±2.93 | 15.06±2.78 | 15.01±2.77 | 14.78±2.66 | 0.51 | 0.23 | 0.18 | 0.31, 1.03 (0.97–1.10) | 0.31, 1.03 (0.97–1.09) | 0.15, 1.03 (0.99–1.08) |
L | 19.31±3.58 | 19.66±3.63 | 19.36±3.69 | 19.47±3.30 | 0.21 | 0.97 | 0.42 | 0.26, 0.97 (0.93–1.02) | 0.69, 0.99 (0.95–1.04) | 0.29, 0.98 (0.95–1.02) | |
Ave. | 17.31±2.86 | 17.36±2.78 | 17.18±2.76 | 17.13±2.53 | 0.85 | 0.74 | 0.91 | 0.84, 0.99 (0.94–1.06) | 0.79, 1.01 (0.95–1.07) | 0.96, 1.00 (0.96–1.04) | |
ESR2_CA | S | 21.36±2.52 | 21.27±3.03 | 21.52±3.05 | 21.02±2.94 | 0.72 | 0.0018 | 0.037 | 0.71, 1.01 (0.95–1.08) | 0.04, 1.06 (1.00–1.11) | 0.07, 1.04 (1.00–1.08) |
L | 23.85±1.76 | 24.20±2.05 | 24.17±2.07 | 23.95±2.02 | 0.036 | 0.11 | 0.84 | 0.04, 0.91 (0.83–1.00) | 0.17, 1.06 (0.98–1.14) | 0.78, 0.99 (0.94–1.05) | |
Ave. | 22.61±1.74 | 22.74±2.13 | 22.84±2.10 | 22.49±2.05 | 0.15 | 0.0047 | 0.26 | 0.45, 0.97 (0.88–1.06) | 0.03, 1.09 (1.01–1.17) | 0.24, 1.04 (0.98–1.10) | |
AR_CAG | S | 18.35±2.60 | 17.83±2.77 | 17.78±2.35 | 17.73±2.30 | 0.038 | 0.82 | 0.12 | 0.03, 1.08 (1.01–1.15) | 0.81, 1.01 (0.94–1.08) | 0.08, 1.04 (1.00–1.09) |
L | 21.73±2.88 | 21.78±2.99 | 21.26±2.70 | 21.38±2.91 | 0.83 | 0.62 | 0.61 | 0.84, 0.99 (0.94–1.05) | 0.58, 0.99 (0.93–1.04) | 0.59, 0.99 (0.95–1.03) | |
Ave. | 20.04±2.38 | 19.81±2.42 | 19.52±2.11 | 19.56±2.22 | 0.50 | 0.98 | 0.64 | 0.26, 1.04 (0.97–1.12) | 0.82, 0.99 (0.92–1.07) | 0.53, 1.02 (0.97–1.07) |
S: Short allele; L: Long allele; Ave.: average repeat length of short and long alleles.
P values <0.0083 were bolded.
Van Elteren’s test.