Table 3. Categorical variable analysis of ESR1_TA, ESR2_CA, and AR_CAG alleles and breast cancer risk in African American and Nigerian women.
| AA | NG | AA + NG | ||||||||||
| Microsatellite | Dichotomous cut-off | Genotype1 | Case, n (%) | Control, n (%) | OR (95% CI) | Logistic regression P | Case, n (%) | Control, n (%) | OR (95% CI) | Logistic regression P 2 | OR (95% CI) | Logistic regression P 2 |
| ESR1_TA | <18 vs. ≥18 | SS | 90 (35.0) | 84 (32.4) | 1.0 (ref.) | 123 (35.2) | 88 (30.0) | 1.0 (ref.) | 1.0 (ref.) | |||
| SL | 115 (44.8) | 138 (53.3) | 0.78 (0.53–1.15) | 173 (49.6) | 164 (56.0) | 0.75 (0.53–1.07) | 0.77 (0.59–0.99) | |||||
| LL | 52 (20.2) | 37 (14.3) | 1.31 (0.78–2.20) | 53 (15.2) | 41 (14.0) | 0.92 (0.57–1.51) | 1.09 (0.77–1.56) | |||||
| Total | 257 | 259 | 0.089 | 349 | 293 | 0.26 | 0.039 | |||||
| LL vs. SS + SL | 1.52 (0.96–2.42) | 0.075 | 1.10 (0.71–1.71) | 0.67 | 1.29 (0.93–1.77) | 0.12 | ||||||
| SL + LL vs. SS | 0.89 (0.62–1.28) | 0.53 | 0.79 (0.57–1.10) | 0.16 | 0.83 (0.65–1.07) | 0.15 | ||||||
| ESR2_CA | <23 vs. ≥23 | SS | 26 (10.1) | 22 (8.5) | 1.0 (ref.) | 29 (8.3) | 28 (9.5) | 1.0 (ref.) | 1.0 (ref.) | |||
| SL | 111 (43.0) | 113 (43.6) | 0.83 (0.44–1.55) | 125 (358) | 148 (50.0) | 0.82 (0.46–1.44) | 0.82 (0.54–1.25) | |||||
| LL | 121 (46.9) | 124 (47.9) | 0.83 (0.44–1.54) | 195 (55.9) | 120 (40.5) | 1.57 (0.89–2.77) | 1.17 (0.77–1.78) | |||||
| Total | 258 | 259 | 0.82 | 349 | 296 | 0.0004 | 0.016 | |||||
| LL vs. SS + SL | 0.96 (0.68–1.36) | 0.82 | 1.86 (1.36–2.54) | <0.001 | 1.38 (1.10–1.74) | 0.006 | ||||||
| SL + LL vs. SS | 0.83 (0.46–1.50) | 0.54 | 1.15 (0.67–1.99) | 0.61 | 0.99 (0.66–1.48) | 0.97 | ||||||
| AR_CAG | <20 vs. ≥20 | SS | 66 (25.6) | 61 (23.6) | 1.0 (ref.) | 101 (29.0) | 87 (29.5) | 1.0 (ref.) | 1.0 (ref.) | |||
| SL | 125 (48.4) | 138 (53.3) | 0.84 (0.55–1.28) | 180 (51.7) | 154 (52.2) | 1.01 (0.70–1.44) | 0.93 (0.71–1.22) | |||||
| LL | 67 (26.0) | 60 (23.2) | 1.03 (0.63–1.69) | 67 (19.3) | 54 (18.3) | 1.07 (0.68–1.69) | 1.06 (0.76–1.48) | |||||
| Total | 258 | 259 | 0.54 | 348 | 295 | 0.95 | 0.67 | |||||
| LL vs. SS + SL | 1.16 (0.78–1.74) | 0.46 | 1.06 (0.72–1.58) | 0.76 | 1.11 (0.84–1.48) | 0.46 | ||||||
| SL + LL vs. SS | 0.90 (0.60–1.34) | 0.59 | 1.02 (0.73–1.44) | 0.90 | 0.97 (0.75–1.25) | 0.80 | ||||||
| AR_CAG | <22 vs. ≥22 | SS | 124 (48.1) | 127 (49.0) | 1.0 (ref.) | 192 (55.2) | 155 (52.5) | 1.0 (ref.) | 1.0 (ref.) | |||
| SL | 102 (39.5) | 110 (42.5) | 0.95 (0.66–1.37) | 130 (37.4) | 122 (41.4) | 0.86 (0.62–1.19) | 0.90 (0.70–1.15) | |||||
| LL | 32 (12.4) | 22 (8.5) | 1.49 (0.82–2.71) | 26 (7.5) | 18 (6.1) | 1.17 (0.62–2.21) | 1.33 (0.86–2.05) | |||||
| Total | 258 | 259 | 0.33 | 348 | 295 | 0.52 | 0.21 | |||||
| LL vs. SS + SL | 1.53 (0.86–2.70) | 0.15 | 1.24 (0.67–2.31) | 0.49 | 1.39 (0.91–2.12) | 0.13 | ||||||
| SL + LL vs. SS | 1.04 (0.74–1.47) | 0.83 | 0.90 (0.66–1.23) | 0.51 | 0.96 (0.76–1.21) | 0.73 | ||||||
1
S: Short allele; L: Long allele.
2
P values <0.083 were bolded.