Table 3. Mean (± SEM) volumes of brain regions in mm3, adjusted for age and gender.
| Brain Region (mm3) | HC (n = 30) | T1C (n = 22) | WFS (n = 11) | p value |
| Intracranial (ICV) | 1481637±134316 | 1509633±127999 | 1358061±92086 a,b | .005 |
| Whole brain | 1029284±94162 | 1045945±89363 | 940183±84097 a,b | .009 |
| Total cortical gray | 538,744±4231 | 535030±4952 | 538,660±6919 | .84 |
| Total cortical white | 443,439±4787 | 456,997±5603 | 447,066±7829 | .19 |
| Brainstem | 20,560±343 | 19,960±401 | 16,220±560 a,b | <.001 |
| Cerebellum white | 15,635±326 | 14,772±382 | 12,236±534 a,b | <.001 |
| Cerebellum gray | 58,419±761 | 58,314±891 | 52,771±1245 a,b | .001 |
| Thalamus | 7,168±92 | 7,112±107 | 6,585±150 a,b | .005 |
| Pallidum | 1,775±29 | 1,753±34 | 1,630±48 a,b | .04 |
| Total corpus callosum | 3,016±70 | 3,138±82 | 2,883±115 | .19 |
| Hippocampus | 4,306±58 | 4,180±68 | 4,083±95 | .12 |
| Amygdala | 1,706±26 | 1,716±31 | 1,650±43 | .44 |
| Caudate | 3,771±89 | 3,868±105 | 3,987±146 | .44 |
| Putamen | 6,145±106 | 6,120±125 | 6,182±174 | .96 |
| Accumbens | 696±19 | 699±23 | 756±32 | .24 |
Abbreviation. HC: healthy controls; T1C: diabetic controls; WFS: Wolfram Syndrome group; SEM: standard error of the mean.
P values shown are for the main effect of group in univariate GLM analyses for each measure.
Values in bold survived Bonferroni correction for multiple comparisons (p<.0038).
a
different from HC group; bdifferent from T1C group.