Table 4. Mean (±SEM) DTI measures from selected brain regions and adjusted for age and gender.
| BrainRegion | Measure | HC(n = 45) | T1C(n = 9) | WFS(n = 11) | p value |
| Cerebellum | FA | .23±.004 | .22±.01 | .18±.01 a,b | <.001 |
| MD | .70±.01 | .66±.02 | .77±.01 a,b | <.001 | |
| OpticRadiation | FA | .55±.01 | .50±.02 a | .47±.02 a | <.001 |
| MD | .84±.01 | .81±.02 | .87±.02 | .20 | |
| Corpuscallosum | FA | .74±.01 | .77±.01 | .71±.01 b | .009 |
| MD | .80±.01 | .72±.03 | .80±02 b | .03 | |
| PLIC | FA | .68±.01 | .69±.01 | .68±.01 | .68 |
| MD | .69±.01 | .66±.01 a | .68±.01 | .04 | |
| Centrumsemiovale | FA | .33±.01 | .38±.02 | .35±.02 | .12 |
| MD | .84±.02 | .75±.05 | .76±.05 | .11 | |
| Thalamus | FA | .31±.01 | .30±.02 | .30±.02 | .47 |
| MD | .75±.01 | .73±.02 | .73±.01 | .19 | |
| Putamen | FA | .13±.004 | .13±.01 | .14±.01 | .86 |
| MD | .71±.004 | .69±.01 | .69±.01 | .06 | |
| Hippocampus | FA | .17±.01 | .16±.01 | .14±.01 | .10 |
| MD | .88±.03 | .85±.06 | .97±.05 | .22 | |
| Cerebellarpeduncle | FA | .56±.02 | .60±.03 | .57±.03 | .57 |
| MD | .67±.01 | .63±.02 | .66±.02 | .08 | |
| Pons | FA | .45±.01 | .42±.02 | .40±.02 a | .03 |
| MD | .72±.01 | .74±.02 | .71±.02 | .65 |
Abbreviation. HC: healthy controls; T1C: diabetic controls; WFS: Wolfram Syndrome group; SEM: standard error of the mean; PLIC: posterior limb of the internal capsule.
P values shown are for the main effect of group in univariate GLM analyses for each measure.
Values in bold survived Bonferroni correction (p<.005) for multiple comparisons.
a
different from HC group; bdifferent from T1C group.