Table 3. Literature data for expression of selected PTPs in purified cells from rodent brain.
Ptpn18 | Ptprq | Ptpn22 | Dusp9 | Ptprr | Dusp15 | Ptpn5 | ||
In-house data (human) | Fold change (WML vs CWM: WML vs NAWM) | −15/−14 | +160/+243 | +37/+78 | +26/+30 | +14/+9 | +8/+13 | +8/+5 |
Cahoy et al , 2007 a (mouse) [38] | Astroglia (DIV12 culture, 69E) | 40 | No dataavailable | 17 | 7 | 37 | 34 | 25 |
Astroglia (DIV12 culture, 79 E) | 68 | 16 | 19 | 34 | 15 | 26 | ||
Astrocytes (P7; 56A) | 23 | 13 | 39 | 38 | 207 | 261 | ||
Astrocytes (P7; 81A) | 18 | 16 | 36 | 41 | 183 | 272 | ||
Astrocytes (P17; 72A) | 35 | 31 | 32 | 34 | 206 | 177 | ||
Neurons (P7; 81b) | 38 | 8 | 28 | 498 | 147 | 1130 | ||
Neurons (P16n; 61D) | 22 | 12 | 15 | 489 | 206 | 1069 | ||
OPCs (P17, 80O) | 23 | 6 | 257 | 495 | 379 | 807 | ||
OLs (P17, 80P) | 26 | 9 | 759 | 432 | 3161 | 248 | ||
Myelinating-OL (P17, 80Q) | 59 | 11 | 76 | 172 | 3191 | 65 | ||
Nielsen et al , 2006 b (rat) (42) | OPCs (A2B5+ O4-) | 1.3 | 0.4 | No data av. | 0.5 | 1.2 | 0.4 | 1.3 |
Myelinating OLs (A2B5+ O4+) | 1.1 | 0.5 | 0.6 | 1.0 | 8.9 | 1.0 |
Data extracted from GEO dataset GSE9566: GSM241928 (56A); GSM241929 (61D); GSM241930 (69E); GSM241931 (72A); GSM241932 (79E); GSM241933 (80O); GSM241934 (80P); GSM241935 (80Q); GSM241936 (81A); GSM241937 (81B). Samples designations correspond to the one used by the cited authors. Cell types were purified from post-natal mouse forebrains using FACS analysis. For more details see Cahoy et al, 2007.