Table 4. Fold-changes in mRNA expression for selected PTPs in several MS-related samples.
| MS patients WML vs CTRL WM | EAE mice spinal cord MOG vs SHAM | Mouse Mixed cortical DIVs vs DIV5 | Oli-neu PD174265 vs CTRL | |||||
| Fold increase | Pval | Fold increase | Pval | Fold increase | Pval | Fold increase | Pval | |
| DUSP4 | 6.13 | 0.0110 | −1.56 c | 0.0383 | −4.64 b | 0.0157 | −5.88 c | 0.0014 |
| DUSP6 | 5.88 | 0.0142 | 2.42 b | 0.0028 | −1.62 b | 0.0421 | −4.55 c | 0.0010 |
| DUSP15 | 8.51 | 0.0015 | −2.40 b | 0.0005 | 5.41 b | 0.0151 | 2.6 c | 0.0327 |
| TNS3 | 1.72 | 0.0281 | 3.37 b | 0.0002 | 4.60 b | 0.0061 | 4.3 b | 0.0129 |
| PTPN2 | 4.57 | 0.0071 | 1.74 b | 0.0137 | 1.99 a | 0.0412 | −3.80 a | 0.0104 |
| PTPN5 | 8.00 | 0.0051 | −1.72 b | 0.0050 | −3.29 b | 0.0097 | −3.83 c | 0.0219 |
| PTPRD | −4.12 | 0.0006 | −2.44 b | 0.0010 | −2.43 b | 0.0129 | −3.39 a | 0.0112 |
| PTPN13 | −3.55 | 0.0114 | −1.82 c | 0.0026 | 2.75 a | 0.0272 | 2.8 b | 0.0224 |
| PTPN18 | −15.47 | 0.0038 | 4.42 a | 0.0225 | 1.55 a | 0.0105 | d | n.s |
| PTPRN2 | 7.09 | 0.0012 | −2.24 b | 0.0003 | 2.46 b | 0.0434 | e | |
| PTPN22 | 37.12 | 0.0267 | 10.69 b | 0.0012 | 1.67 a | 0.0035 | d | n.s |
| DUSP5 | −3.69 | 0.0160 | 3.22 b | 0.0042 | 11.28 c | 0.0334 | −1.3 c | 0.0400 |
| DUSP2 | 3.07 | 0.0155 | 6.03 b | 0.0046 | −8.45 c | 0.0025 | a | n.s |
| DUSP8 | 4.47 | 0.0166 | −1.79 c | 0.0005 | −2.50 c | 0.0181 | d | n.s |
| EPM2A | 3.08 | 0.0114 | −1.93 c | 0.0001 | 10.01 b | 0.0150 | d | n.s |
| PTPRR | 14.62 | 0.0089 | −1.94 b | 0.0059 | 2.91 c | 0.0358 | −2.8 a | 0.0085 |
| P<0.05 | P<0.05 | P<0.05 | P<0.05 | |||||
| Additional PTP | ||||||||
| PTPRO | 1.10 | 0.280 | 1.45 a | 0.0277 | −4.27 c | 0.0135 | −1.6 c | 0.0655 |
| a 14 days post-immunization | a DIV8/DIV5 | a 24 h post-treatment | ||||||
| b 17 days post-immunization | b DIV12/DIV5 | b 48 h post-treatment | ||||||
| c 28 days post-immunization | c DIV15/DIV5 | c 72 h post-treatment | ||||||
| d no modulation at any time | ||||||||
| e not expressed | ||||||||