Table 3. Crude and Adjusted Odds Ratios* for prediction of poor pregnancy outcome after presentation with RFM.
| Variable | Median (range) or n | Crude Odds Ratio | Confidence Interval | p value | Adjusted Odds Ratio* | Confidence Interval | p value |
| Gestation at presentation (days) | 254 (196–294) | 1.00 | 0.99–1.01 | 0.29 | 0.99 | 0.97–0.99 | 0.026 |
| Gestation at presentation <37 weeks | n = 172 | 0.97 | 0.92–1.01 | 0.14 | 0.95 | 0.90–1.00 | 0.048 |
| Maternal Age | 28 (17–46) | 1.00 | 0.95–1.05 | 0.95 | 1.04 | 0.98–1.10 | 0.24 |
| Maternal BMI | 25.2 (17.2–52.8) | 0.98 | 0.94–1.03 | 0.46 | 1.01 | 0.95–1.08 | 0.71 |
| Gravidity | 2 (1–9) | 0.93 | 0.77–1.12 | 0.43 | 0.97 | 0.77–1.23 | 0.82 |
| Parity | 1 (0–7) | 0.94 | 0.72–1.13 | 0.63 | 0.99 | 0.72–1.37 | 0.95 |
| Smoking (Yes/No) | n = 43 | 1.96 | 0.96–4.00 | 0.06 | 1.55 | 0.55–3.68 | 0.32 |
| Alcohol (units/week) | 0 (0–6) | 0.77 | 0.31–1.87 | 0.56 | 0.72 | 0.19–2.68 | 0.62 |
| Duration of RFM (hours) | 48 (3–1690) | 1.00 | 1.00–1.01 | 0.55 | 1.00 | 0.99–1.00 | 0.55 |
| Significant Medical History (Yes/No) | n = 36 (11.8%) | 1.01 | 0.44–2.33 | 0.99 | 0.88 | 0.32–2.46 | 0.81 |
| Significant Obstetric History (Yes/No)# | n = 15 (9.6%) | 1.35 | 0.40–4.53 | 0.63 | 1.61 | 0.36–7.35 | 0.54 |
| FMs normalised to 45 minutes | 9 (0–72) | 0.96 | 0.92–0.99 | 0.022 | 0.98 | 0.95–1.02 | 0.28 |
| Abnormal CTG (Yes/No) | n = 12 | 8.04 | 2.34–27.62 | 0.001 | 7.08 | 1.31–38.18 | 0.02 |
| Further episodes of RFM (Yes/No) | n = 69 | 1.15 | 0.91–1.46 | 0.24 | 1.03 | 0.75–1.42 | 0.86 |
| Systolic blood pressure (mmHg) | 110 (80–150) | 1.02 | 1.00–1.04 | 0.078 | 1.00 | 0.96–1.04 | 0.92 |
| Diastolic blood pressure (mmHg) | 60 (50–114) | 1.05 | 1.01–1.08 | 0.004 | 1.04 | 1.00–1.09 | 0.045 |
| Estimated fetal weight centile | 53 (0–100) | 0.95 | 0.94–0.97 | <0.001 | 0.95 | 0.94–0.97 | <0.001 |
| Amniotic fluid index (cm) | 125 (10–252) | 0.99 | 0.99–0.99 | 0.019 | 0.99 | 0.98–1.00 | 0.13 |
| Maximum pool depth (cm) | 51 (0–133) | 0.97 | 0.96–0.99 | 0.002 | 0.99 | 0.96–1.01 | 0.28 |
| Abnormal Umbilical Artery Doppler | n = 1 | NA† | NA† | NA† | NA† | NA† | NA† |
| Umbilical Artery Pulsatility Index | 0.8 (0.5–1.4) | 3.29 | 0.75–14.42 | 0.12 | 2.96 | 0.38–23.21 | 0.30 |
| Log hCG | 4.20 (2.85–5.09) | 0.67 | 0.48–0.92 | 0.015 | 0.88 | 0.32–2.46 | 0.81 |
| Log hPL | 2.54 (2.15–3.12) | 0.23 | 0.11–0.47 | <0.001 | 0.13 | 0.02–0.99 | 0.05 |
| Log IMA | 1.97 (1.42–2.14) | 0.60 | 0.22–1.61 | 0.31 | 0.53 | 0.04–7.91 | 0.65 |
| Log LDH | 2.70 (2.36–2.94) | 2.67 | 0.70–10.17 | 0.15 | 5.42 | 0.11–278.74 | 0.40 |
| Log PAPP-A | 2.67 (1.63–4.52) | 0.94 | 0.77–1.14 | 0.50 | 0.78 | 0.44–1.38 | 0.39 |
| AFP | 70.9 (1.7–232.2) | 0.99 | 0.99–1.00 | 0.23 | 0.99 | 0.99–1.00 | 0.13 |
| Progesterone | 369.1 (167.9–777.8) | 0.99 | 0.99–1.00 | 0.079 | 1.00 | 1.00–1.00 | 0.73 |
*
Adjusted for gestation, number of fetal movements normalised to 45 minutes, abnormal CTG, diastolic blood pressure, estimated fetal weight centile, maximal pool depth and smoking status.
#
only calculated for parous participants.
†
Odds ratios could not be calculated as only one infant had abnormal umbilical artery Doppler at initial assessment.